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Propolis extract is a natural product from bees called "bee glue" used for hive construction and maintenance, which has the potential to be characterized as an antioxidant and anti-inflammatory agent. This project is a STEM project led by 13–14-year-old students aiming to investigate the effect of propolis extract on bacteria in microgravity. If the experiments prove that propolis extract can exhibit anti-microbial properties in space, it could open avenues for future research on new and natural product-based cleaning agents for future spaceflight applications.