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This portfolio of projects will look at how humans adapt and respond to spaceflight to better understand human physiology in microgravity, which will contribute to our understanding of how to keep humans healthy in space. Projects utilizing novel neuroscience tools include measuring blood flow to the brain and the brain’s electrical activity, assessing intracranial pressure by non-invasive assessment of the pupil of the eye, and monitoring changes in the optic nerve over time. Improved monitoring of neurological health may help make spaceflight safer in the future and allow for the development of rapid, non-invasive monitoring, as well as early interventions and the development of countermeasures. Blood and bio-sample specimens will also be taken to examine multi-omic biomarkers related to spaceflight and also to map changes in the length, structure, and epigenetics of chromosomes and telomeres.