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Elevated stress can affect essential functions controlled by the central nervous system (CNS) such as memory, ability to concentrate, sleep, and fine-motor skills. Evaluating Stress Levels Among Space Travelers by Monitoring Changes In Their Central Nervous System Functions [Monitoring Stress (Ax-1)] on the Axiom-1 (Ax-1) private astronaut mission (PAM) examines whether the development of emotional distress can be detected by continuous monitoring of basic CNS functions. Results could support development of tools for early intervention to help maintain the well-being and performance of crew members on future long-duration missions. The work also could have applications for hospitalized or quarantined individuals on Earth.