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The Space Frontier and Extraterrestrial Cardioprotection (Cardioprotection Ax-1) performs cardiovascular evaluation on Axiom Mission 1 (Ax-1) private astronaut mission (PAM) crew members. Human research in space has, to date, focused on professional astronauts, but as spaceflight opportunities expand, more diverse populations experience exposure to the space environment. The study supports protection of heart health in this expanding population.