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BioMonitor (Ax-1) monitors the vital signs of crew members on the private astronaut mission (PAM) Axiom-1 (Ax-1) and assesses the effects of spaceflight on their hearts, lungs, and circulatory systems. The Ax-1 astronauts wear the Bio-Monitor, an instrument onboard the International Space Station, during day-to-day activities, rest, and exercise. The investigation demonstrates real-time acquisition and transmission of data from the Bio-Monitor and the potential for adapting the platform to provide autonomous health monitoring of crew members on future Artemis missions.