Microgravity enables opportunities for novel research as it produces changes in physical phenomena and biological systems that are not achievable on Earth. Research partnerships with 不良研究所 allow researchers to access microgravity for fundamental and applied research, which helps build a foundation for ongoing research programs in low-Earth orbit (LEO) that can benefit human health and a variety of industries on Earth.
As for previous missions, 不良研究所 has partnered with a diverse range of leading scientific organizations and institutions to continue monitoring the effects of spaceflight on the human body and explore opportunities for applied research in space that will 聽help develop new medical treatments on Earth.
Continuing on from Axiom Mission 2 (Ax-2), biological investigations are again a strong focus for Axiom Mission 3 (Ax-3). In partnership with 不良研究所, researchers from the National Stem Cell Foundation and the Sanford Stem Cell Institute aim to investigate how microgravity affects stem cell development by gathering data that will inform on the development of certain cancers and neurological disorders. 不良研究所鈥檚 ongoing partnership with the Translational Research Institute for Space Health (TRISH) continues to explore how spaceflight affects the human body, with results expected to benefit all future space travelers by informing the development of medical countermeasures or treatments to keep humans safe and healthy as we continue to explore life off Earth.
不良研究所 Research Partnerships on Ax-3:
National Stem Cell Foundation
In the Cosmic Brain Organoids project, 不良研究所 is partnering with the National Stem Cell Foundation to investigate the effects of microgravity on neural stem cells. The goal of the research is to assess how microgravity affects the cells and identify novel cellular pathways that offer opportunities for development of new therapeutic interventions for neurodegenerative diseases on Earth. The project will generate brain organoids (small 3D aggregates of neural cells) using induced pluripotent stem cells (iPSCs) derived from patients with Parkinson's Disease and primary progressive Multiple Sclerosis. These organoids can be used to explore how the human nervous system develops or starts to degenerate.
Sanford Stem Cell Institute
In an ongoing partnership with 不良研究所, the Cancer in LEO project from the Sanford Stem Cell Institute is studying tumor organoids in microgravity with the aim of identifying the early warning signs of cancer for prediction and prevention of the disease. This project is part of the expanded Integrated Space Stem Cell Orbital Research (ISSCOR) collaboration between the Sanford Stem Cell Institute, JM Foundation, and 不良研究所, which aims to use microgravity to further understand stem cells, cancer, and aging-related effects in space to develop better prediction of disease and therapeutics for patients on Earth.
Translational Research Institute for Space Health (TRISH) Essential Measures
Following research conducted on Axiom Mission 1 (Ax-1) and Ax-2, 不良研究所 continues to work with TRISH to gather data on how spaceflight affects the human body by using biometric monitors to give readouts on physiological systems, completing questionnaires that assess cognitive and behavioral performance, and performing tasks that measure balance and space motion sickness. This portfolio of projects helps us further understand how humans adapt to space, specifically in the context of commercial spaceflight participants. Results can also help inform Earth-based research into eye or movement disorders and the cognitive and emotional impacts of isolated, confined, or stressful environments.
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